This Brief describes a study (conducted 2020-2023) of the effectiveness of seven STARTALK programs in developing language proficiency, cultural competence, and 21st-century skills of the learners involved. The study examined best practices, instructional methodologies used, and areas for improvement. Key findings highlight STARTALK's strengths, including its emphasis on communicative competence, the integration of cultural elements into language instruction, and the use of performance-based assessments. Challenges remain, particularly in adapting to online learning and enhancing grammar instruction. The Brief provides a summary of the study's findings and their implications for future language education programs.